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A Longevity Regulator Gene? (Wednesday July 19 2006) It's good to see that the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging is already appearing on published research. Via PubMed: "Eukaryotes have evolved elaborate mechanisms to survive periods of adversity. By manipulating genes that control these mechanisms, researchers have found they can generate more stress resistant, longer-lived organisms. One of these is the PNC1 gene of [budding yeast], a master 'longevity regulatory gene' that translates a variety of environmental stresses into lifespan extension by activating the sirtuin family of longevity deacetylases. ... We propose that there is a functional equivalent of PNC1 in mammals called Nampt (a.k.a. PBEF/Visfatin), a stress-responsive gene that would coordinately regulate metabolism, cell defenses, and resistance to diseases of aging." There are those who see this sort of metabolic research as a dead-end: interesting and useful within its range, but not likely to produce ongoing significant healthy life extension. Link to original article   Share |

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