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Update on Telomere Length and Heart Disease
(Thursday January 11 2007)
 | Scientists have been looking into telomere length and age-related decline for a number of years now: "The researchers, who measured telomere length in leukocytes, or white blood cells, in 1,500 men aged 45-64 years old, found short telomeres indicate a higher likelihood of developing heart disease. ... Telomeres protect the ends of chromosomes from fraying. They shorten each time a cell divides and the loss is associated with ageing. As telomeres get smaller, the chromosomes can become unstable and at greater risk of mutation. Earlier research had shown that people with heart disease have shorter telomeres but it was not clear until now if telomere length could be a predictive marker for the illness. ... They have shown that it is a predictor. It doesn't say it is functionally linked to heart disease but it is certainly associated with it." The next steps involve a better understanding of how this all fits together - is more pronounced telomere shortening only a symptom of years of stressed and worn biochemistry, or is it sufficiently high in the chain of cause and effect to merit preventative therapies aimed at reducing the progression of age-related decline? |
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