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Theorizing on Germline Cells and Induced Longevity
(Monday June 08 2009)
 | An interesting line of thought via EurekAlert!: "In the sense that organisms existing today are connected through a chain of life - through their parents, grandparents and other ancestors - almost a billion years back to the first animals of the pre-Cambrian era, an animal's reproductive cells can be considered to be immortal. These germline cells generate their offspring's somatic cells - other cells involved in all aspects of growth, metabolism and behavior, which have a set lifespan – and new germline cells that continue on, generation after generation. [Researchers] have found that certain genetic mutations known to extend the lifespan of the C. elegans roundworm induce 'mortal' somatic cells to express some of the genes that allow the 'immortality' of reproductive germline cells. ... The idea that somatic cells can reacquire genetic pathways usually restricted to germline cells is fascinating, and since germline protection is seen across species, the activity of these genes may play a role in controlling mammalian lifespan. Understanding the mechanisms involved in this transformation could help us develop new ways to repair and even regenerate key cells and tissues." |
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