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Rapamycin Reviewed at Ouroboros
(Wednesday February 03 2010)
 | From Ouroboros: "One of [the] most significant breakthroughs [in biogerontology] last year was the announcement that the macrolide drug rapamycin can extend longevity in mice. More specifically, rapamycin can accomplish this when administered to adult, wildtype mice. In other words, no genetic modification or early-life intervention is necessary, making rapamycin one of the first compounds that meets the criteria for an anti-aging drug that could be used for people who are already alive and well down the road toward aging themselves. The lifespan extension achieved is modest (~10%), but this is more impressive in light of the fact that the mice were quite old at the time treatment began, and the study used only a single dose rate. Future studies will undoubtedly seek to optimize the dose and regimen with the goal of achieving greater enhancement of lifespan. How does it work? As the saying goes, further study is required, and at multiple levels. ... There's a good deal left to discover about the rapamycin’s effects on aging in general - and regarding the specific mechanistic relationship between translational control, senescence, and organismal aging - but I have it on good authority that there's a great deal of effort being exerted in that direction. Watch this space for future developments." |
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